A field experiment was conducted during rabi (winter) season of 2020 at Main Agricultural Research Station,Dharwad, Karnataka, India to evaluate the efficacy of tank mix post emergence herbicides on growth and yield in irrigatedwheat. The experiment consisted of ten treatments and was laid out in Randomised Complete Block Design. Amongdifferent weed management practices, significantly lower weed density, higher growth and yield parameters were recordedwith the recommended weed management practice (RWMP) of pendimethalin 30% EC 1 kg ha-1 as PE + one hand weeding.Among the herbicidal treatments, significantly higher plant height, number of tillers, leaf area index and total dry matterproduction was recorded with post-emergence tank mix application ofmetsulfuron-methyl 20% WP + carfentrazone-ethyl20% DF @ 4+20 g ha-1 followed by metsulfuron-methyl 20% WP + sulfosulfuron 75 % WG @ 4 + 25 g ha-1 overmetsulfuron-methyl 20% WP @ 4 g ha-1 alone. The yield components like number of productive spikes per m-2, number ofgrains per spike, grain weight per spike and thousand grain weight were higher in the treatment receiving post-emergencetank mix application of metsulfuron-methyl 20% WP + carfentrazone-ethyl 20% DF @ 4+20 g ha-1. Significantly highergrain and straw yield were obtained with the tank mix post emergence application of metsulfuron-methyl 20% WP +carfentrazone-ethyl 20% DF @ 4+20 g ha-1 (4047 and 6511 kg ha-1) but weed free treatment recorded superior harvest index(38.69%) and was found on par with all other treatments except weedy check (34.42%).Key words: Carfentrazone-ethyl, Herbicide mixture, Metsulfuron-methyl, Post-emergence