Abstract: A field experiment was conducted at MARS, University of Agricultural Sciences, Dharwad, Karnataka during rabi season 2022-23 on Vertisols to evaluate the suitability of site specific nutrient management on growth and yield of Indian mustard (Brassica juncea L.) genotypes through targeted yield approach for fertilizer recommendations. The experiment was laid out in strip plot design, horizontal strips with four genotypes viz., TDM-304-1, TDM-304-1, TDM304-1 and NRCHB-101 and vertical strips with three targeted yield levels viz., 15, 20 and 25 q ha-1. Genotype TDM-305- 1 recorded significantly higher seed yield (1622 kg ha-1) over other genotypes. SSNM based fertilizer application for 20 q ha-1targeted yield recorded significantly higher seed yield (1633 kg ha-1) over 15 and 20 q ha-1. In interaction, genotype TDM-305-1 with a target yield level of 20 q ha-1 recorded higher seed yield (1789 kg ha-1) as compared to rest of the treatment combinations. The better yield response of improved genotype TDM-305-1 at 20 q ha-1 yield target recoded significantly higher net returns (`49463 ha-1) and B:C ratio (2.59). From the present investigation, it was found that genotype TDM-305-1 at 20 q ha-1 yield target recorded significantly higher nutrient uptake of NPK & S and the oil content (39.4%) and oil yield (702.2 kg ha-1).