The present investigation on a line x tester analysis of 19 parents and 90 crosses in sesame indicated that the character, 1000-seed weight had a fixable additive genetic variance which can be improved by simple selection, whereas the characters viz., plant height, days to 50 per cent flowering, days to maturing, length of the capsule, total number of capsules per plant, oil content, seed yield per plant and seed yield per ha showed the predominance of non-additive gene action which can be improved by biparental mating. The parents DS-13, DS-16, DS-10 (females) and E-8, TSES-2, TSES-4, DS-1 (males) were fond to be good combiners for seed yield per plant. The combinations of DS-16 x DS-1 and DS-16 x TSES-2, which combine high sca effect for seed yield per hectare.