An experiment was conducted during 2004-05 (Rabi) on medium black soil at Main Agricultural Research Station, University of Agricultural Sciences, Dharwad to study the response of wheat genotypes to different planting method and seed treatments on growth, yield, quality and bio-chemical parameters under rainfed condition. The study indicated that the data on growth, yield, quality and bio-chemical properties differed significantly due to combination of genotypes with method of planting and seed treatment. Among genotype and method of planting combinations, Bijaga yellow with skipping one row after every three rows recorded significantly more plant height, leaf area, no. of ear heads per m2 area, grain yield, straw yield, chlorophyll “a”, chlorophyll “b”, total chlorophyll content and proline content as compared to bijaga yellow with flat bed, DWR-2006 with flat bed and skip row method of planting. DWR-2006 with skip row and flat bed method of planting accounted for higher protein, b-carotene and grain appearance score as compared to other treatment combinations. Among seed treatments, seed treatment with cow urine and CaCl2 recorded significantly higher plant height, leaf area, no. of ear heads per m2 area, grain yield, straw yield, chlorophyll “a”, chlorophyll “b”, total chlorophyll content and proline content as compared to seed treatment with water and without seed treatments. The interaction effect was found to be non-significant.