Field investigations were carried out to evaluate the efficacy of econeem (a neem based formulation) alone and a in combination with HaNPV and Bt against the bollworm, Helicoverpa armigera (Hubner) in cotton. Econeem @ 10 ppm/ha and along with Bt proved equally effective as that of monocrotophos in reducing bollworm egg incidence. The larval load in econeem 10 ppm/ha, econeem (5 ppm/ha) + Bt, econeem (5 ppm/ha) + HaNPV and monocrotophos remained statistically on par, thus providing to be equal in their efficacy. Econeem in combination with microbial pesticides reduced the boll damage to an extent of 70.36 to 71.99 per cent and recorded maximum kapas yield.