Field experiment was conducted during 2007-08 on plant crop of sugarcane to study its response to different nutrient management practices. Two sugarcane varieties viz., Co 62175 and Co 86032 were tried with eight nutrient management practices. Among the nutrient management practices, five were organic in nature, two integrated and the rest was only through chemical fertilizers. The uptake of major nutrients viz., Nitrogen, phosphorus and potassium (NPK) was studied at 6 months, 9 months and at harvest of plant crop of sugarcane. The paradigm indicated that NPK uptake was higher with Co 62175 compared to Co 86032 in all the stages of crop growth. Among the nutrient management practices, significantly higher nitrogen (463.05 kg ha-1) and phosphorus (34.26 kg ha-1) uptake was registered with recommended package of practices (RPP) at harvest stage and potassium uptake (239.34 kg ha-1) at 6 months stage. Higher uptake resulted in higher sugarcane production across varieties and nutrient management practices. The residual soil fertility indicated significantly higher available soil nitrogen with N3 (332.52 kg ha-1)