A field experiment was conducted during kharif, 2010 at Agricultural College Farm, Raichur to study the effect of macro and soluble micronutrients on growth and yield of Bt cotton (Gossypium hirsutum L.) under irrigation. The results revealed that application of 125 per cent RDF (187.5 : 93.5 : 93.5 kg NPK ha-1) in combination with 0.5 per cent tracel micronutrient recorded the highest seed cotton yield per ha and per plant, lint index, nitrogen and phosphorus uptake and gross returns (19.88 q ha-1, 96.99 g plant -1, 5.20, 111.94 and 32.34 kg ha-1 and ` 79,533 ha-1, respectively) whereas, in the absence of foliar nutrition with 100 per cent RDF alone recorded the lowest seed cotton yield per ha-1 and per plant, lint index, ginning percentage, uptake of nitrogen and phosphorus and gross returns (12.12 q ha-1, 59.09 g plant-1, 4.69, 32.69 %, 88.13 and 18.51 kg ha-1 and ` 48,462 ha-1, respectively), but application of 125 per cent RDF with the foliar spray of 1 per cent mangala MgSO4 recorded the highest ginning percentage (34.70) and application of 100 per cent RDF (150:75:75 kg NPK ha-1) without foliar spray recorded the lowest ginning percentage (32.67) whereas, application of 125 per cent RDF with the foliar spray of 0.5 per cent tracel micronutrient recorded the highest uptake of potassium (115.52 kg ha-1) and lowest uptake (89.58 kg ha-1) in absence of water soluble micronutrients when compared to RDF levels and foliar spray of water soluble micronutrients alone.