Field experiment was conducted at Agricultural Research Station, Devihosur in black clayey soil under rainfed condition during kharif/rabi seasons of 2004-05 and 2005-06. The experiment was laid out in split plot design. The treatments comprised of two chilli genotypes (cv. Byadagi kaddi and Hy. 9646) with Jayadhar cotton as mixed crop (main plot) and six intercrops viz., soybean, french bean, coriander (vegetable), coriander (seeds), garlic and onion (sub-plots). In present investigation, high yielding chilli Hy. 9646 recorded significantly higher dry chilli yield of 1013 kg per ha accounting for 37.4 per cent increase in yield over chilli cv. Byadagi (737 kg/ha). Chilli Hy. 9646 recorded significantly higher chilli yield per plant (99.5 g/plant) and hundred fruit weight (97.6 g/plant). Intercropping coriander (vegetable) with chilli + cotton recorded significantly higher dry chilli yield (1122 kg/ha) to the tune of 162.7 per cent over intercropping soybean (427 kg/ha) with chilli + cotton. In present investigation, yield of cotton was not appreciably affected due to chilli genotypes tried. Intercropping coriander (vegetable) with chilli + cotton recorded significantly higher kapas yield of cotton (580 kg/ha) to the extent of 34.31 per cent over intercropping soybean with chilli + cotton (432 kg/ha), due to increased number of bolls (19.94/plant) and boll weight (3.27 g/plant) and higher uptake of nitrogen (50.91 kg/ha), phosphorus (6.90 kg/ha) and potassium (59.34 kg/ha). Chilli cv. Byadagi recorded significantly higher chilli equivalent yield (2189 kg/ha) in chilli + cotton system. Intercropping garlic with chilli (cv. Byadagi) + cotton recorded highest chilli equivalent yield (3257 kg/ha). Productivity efficiency in terms of total economic yield was higher (25.17 kg/ha/day) with intercropping onion with chilli + cotton. Intercropping onion with chilli (cv. Byadagi) + cotton recorded significantly higher productivity efficiency in terms of total economic yield (26.17 kg/ha/day). Intercropping garlic with chilli + cotton recorded significantly higher gross returns of ` 117523 per ha. Intercropping garlic with chilli (cv. Byadagi) + cotton recorded significantly higher gross returns (` 119406/ha) and was at par with intercropping garlic with chilli (Hy. 9646) + cotton (` 115640/ha). Net returns were significantly higher (` 58319/ha) with chilli genotype cv. Byadagi compared to chilli genotype Hy. 9646. Intercropping garlic with chilli + cotton recorded significantly higher net returns (Rs. 84206/ha). Intercropping garlic with chilli (cv. Byadagi) + cotton recorded significantly higher net returns (` 87089/ha). Chilli cv. Byadagi with intercropping chilli + cotton cropping system recorded significantly higher B:C ratio of 2.60 compared to Hy. 9646 (2.16). Intercropping onion with chilli + cotton accounted significantly higher B:C ratio (3.41). Intercropping onion with chilli (cv. Baydagi) + cotton recorded significantly higher B:C ratio (3.87).