Field screening of new fungicide molecules and botanicals against Asian soybean rust in cited by Phakopsora pachyrhizi Syd. was taken up during kharif growing season 2011 at Main Agricultural Research Station, Dharwad and R & D Unit,Ugar Sugar works Limited,Ugarkhurd. The thirteen treatments (combination of fungicide and botanical) were tested under natural epiphytotic conditions of rust severity. The results over two locations revealed that among the spray schedules, two sprays of hexaconazole (0.1%) recorded minimum PDI(33.15) followed by two sprays of kresoxim methyl (0.1%) (35.80 PDI). Among the combinations hexaconazole (0.1%) - azadirchtin (0.5%) (36.55 PDI) and kresoxim methyl (0.1%) - azadirchtin (0.5%) (36.95 PDI) were found effective. Spraying with Neem oil alone @ 1% recorded relatively high disease pressure of 47.85 disease severity compared to the unsprayed control (88.9 PDI). The reduction in disease severity and increase in 100 seed weight, number of pods per plant, yield and B:C ratio was observed in above said treatments. Thus, hexaconazole @0.1% or Kresoxim methyl @0.1% either alone or in combination with botanicals were found effective in the management of soybean rust in India.