A field experiment was conducted at Arabhavi located under Western dry zone of Karnataka (agro-climatic zone-3) on a clay loam soil with a pH of 7.6 during kharif season of 2006 and 2007 to study the effect of organic manures and inorganic fertilizers in combination with nitrogen fixing bacteria on yield and economics of cultivation of coleus (Coleus forskohlii Briq. cv. K-8). The experiment was carried out during kharif season 2006 and 2007 under protective irrigation. The pooled results indicated that application of Recommended dose (RD) of NPK (40:60:50 kg/ha) + RD Farm yard manure (FYM 15 t/ha) + neem cake (1 t/ha) + Azotobacter + Azospirillum recorded significantly higher number of tuberous roots per plant (16.43), length of tuberous roots (11.70 cm), girth of tuberous roots (1.71 cm), fresh weight of tuberous roots per plant (211.17 g) and dry weight of tuberous roots per plant (35.00 g). It also recorded highest fresh (8.51 t/ha) and dry tuberous yield (1.41 t/ha), dry matter per cent of tuberous roots (16.52 %), net income (` 22965/ha) and cost : benefit ratio (1 : 1.48) as compared to RD FYM + RD NPK (C:B ratio of 1 : 1.02).