A field experiment was conducted during 2007-08 on plant crop of sugarcane to study its response to differentnutrient management practices. Two sugarcane varieties viz., Co 62175 and Co 86032 were tried with eight nutrient managementpractices. The results revealed that significantly higher sugarcane yield (170.33 t ha-1) was recorded when nutrients were applied with 50 per cent nitrogen through pressmud and 50 per cent NPK through fertilizers + biofertilizers (N6) compared to all other nutrient management practices. Recommended package of practices (RPP) recorded on par sugarcane yields with N6. Among the sugarcane varieties tried, Co 62175 with N6 (V1N6) recorded significantly higher cane yields (187.94 t ha-1) over all the other combinations of variety and nutrient management practices. RPP in combination with both the varieties recorded on par yields with combinations of N6. The yield attributing characters like cane height, cane weight, cane girth and number of millable canes were higher with N6 which were comparable with recommended package of practices of 250: 100:125 kg N: P2O5: K2O ha-1 (N7) . Higher net returns (` 1,05,540 ha-1) and B:C ratio (2.28) were recorded with N6 over all the other nutrient management practices including N7 (2.06). These results indicate the possibility of blending organic and inorganic sources of nutrients for sustainable sugarcane production