A field experiment was conducted during kharif 2007 at the Main Agricultural Research Station, Dharwad to study the response of sesame genotypes to levels of fertilizer and planting geometry. Cultivar DS-1 recorded significantly higher seed and oil yields (788 and 332 kg ha-1, respectively) with application of recommended NPK (40:25:25 kg ha-1) and                       30 x 10 cm planting geometry. DS-1 with 150 per cent recommended NPK recorded higher N uptake (77.57 kg ha-1) over DS-1 with recommended NPK (73.21kg ha-1). P uptake was also higher in same genotype and fertilizer level (3.82 kg ha-1) over cv. DSS- 9 receiving recommended NPK and spacing. Higher soil available N was observed in DS-1 with 150 per cent NPK and 45 x 20 cm (264 kg ha-1) over DSS-9 with recommended NPK and spacing (228 kg ha-1). DS-1 with closer spacing of  30  x 10 cm and 100 per cent NPK resulted in significantly higher net returns and B:C ratio (Rs. 20650 /- and 2.89, respectively).