A field experiment was conducted during kharif 2012-13 at the Agricultural College Farm, Raichur, to study the response of pigeonpea to soil application of micronutrients and foliar spray of macronutrients on yield, yield components, protein yield and economics. The results revealed that the soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % recorded significantly higher leaf area per plant (27.23 dm2 plant-1) and higher chlorophyll content (66.43 %). Interaction effect was significant with soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % which produced significantly higher number of pods per plant (285.89), seed yield per plant (43.14 g) and seed yield per hectare (1390 kg ha-1) followed by soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 00:00:50 @ 0.3 % (1297 kg ha-1). Soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % recorded significantly higher protein content (22.47%), protein yield (288.75 kg ha-1), gross returns (` 55,592 ha-1), net returns (` 36,323 ha-1) and BC ratio (2.89).