A field experiment was conducted on medium black soil during kharif 2013 at the College of Agriculture, University of Agricultural Sciences, Raichur to study chemical weed management in sesame (Sesamum indicum L.). The results revealed that pre-emergence application of alachlor 50 EC @ 0.75 kg a.i. ha-1 + Hand weeding (HW) at 30 days after sowing (DAS) + Intercultivation (IC) at 45 DAS significantly reduced the weed density (6.53/m2), dry weight of weeds (1.80 g/m2) and weed index (16.89%) by increasing the  weed control efficiency (74.24 %). This was followed by post-emergence application of quizalofop ethyl 5 EC @ 40 g a.i. ha-1 at 20 DAS + IC at 45 DAS. Weed free check resulted in significantly higher dry matter production of sesame (29.95 g/plant) followed by pre-emergence application of alachlor 50 EC @ 0.75 kg a.i. ha-1 + HW at 30 DAS + IC at 45 DAS (26.89 g/plant). With regard to the yield and economics, pre-emergence application of alachlor 50 EC @ 0.75 kg a.i. ha-1 + HW at 30 DAS + IC at 45 DAS gave significantly higher seed yield (488 kg ha-1) and higher gross returns (` 57,600 ha-1), net returns (` 29,482 ha-1) but higher BC ratio (2.25) was recorded with application of quizalofop ethyl 5 EC @ 40 g a.i. ha-1 as post-emergence application at 20 DAS + IC at 45 DAS.