Field experiment was conducted during kharif season of two consecutive years (2012 and 2013) at the Agricultural Research Station, Malnoor, University of Agricultural Sciences, Raichur, Karnataka.  The experiment was laid out in randomized block design with three replications. There were 13 treatments involving two pre-emergence herbicides viz., atrazine 50 WP (1250 g a.i. ha-1) or pendimethalin 30 EC (1500 g a.i. ha-1) applied alone or in combination as tank mix or sequence application with post-emergence herbicides viz.,  2, 4-D sodium salt 80 WP (2000 g a.i. ha-1) and  metsulfuron methyl 20 WG (4 g a.i. ha-1).  These were compared with hand weeding, farmers practice and weedy check.  The data revealed that tank mix application of atrazine 50 WP @ 625 g a.i. ha-1 + pendimethalin 30 EC @ 750g a.i. ha-1 applied as pre-emergent gave excellent control of all types of weeds, higher weed control efficiency and lower weed index. This treatment also recorded higher grain yield (6.63 t ha-1), net returns (` 68093 ha-1) and benefit cost ratio (4.18). Application of metsulfuron methyl 20 EC @ 4.0 g a.i. ha-1, though controlled weeds very efficiently but phytotoxic to maize.