Eighty one genotypes from CIMMYT including some Indian entries/varieties developed by multiple crosses between different leaf rust resistant lines with the aim to achieve the near immunity through pyramiding the resistance genes including slow rusting genes like Lr34 and Lr46 were selected. Wheat genotypes for slow rusting pleiotrophic resistance genes using closely linked Sequence Tagged Sites (STS) and microsatellite markers showed four genotypes (5th CSISA-HTEM-10205, 5th CSISA-HTEM-10209, 5th CSISA-HTEM-10229 and 2WYCYT6) with Lr34/Yr18/Pm38, five genotypes (GW-322, HD-2932, 2 WYCYT16, 2 WYCYT19 and 2 WYCYT32) with Lr46/Yr29/Pm39. In the field these genotypes recorded low ACI, low AUDPC, medium pustule size and density and less rate of infection with good quantity of yield per hectare. However, genotypes DWR-195, DWR-162 and MACS-2496 recorded maximum ACI and relevant adverse values compared to slow leaf rusting genotypes and identified as fast rusters. This study indicates that these genotypes have potential durable resistance and multiple disease resistance genes, which can be used for durable rust resistance breeding programme as well as they can be grown in a larger area without affecting wheat production.