A field experiment was conducted during kharif 2010-11 and 2011-12 to study the effect of tillage (conventional tillage, zero tillage and minimum tillage), mulching (no mulch and with mulch) and weed management practices (unweeded check, atrazine and atrazine followed by 2,4-D spray) in maize at the Main Agricultural Research Station, University of Agricultural Sciences, Dharwad, Karnataka. Tillage, mulching and weed management practices significantly influenced the growth and yield of maize. Grain (59.1 q ha-1) and stover yield (8.1 t ha-1) of maize were significantly higher in conventional tillage system as compared to other tillage practices. Mulching practices showed higher mean grain (57.5 q ha-1) and stover yield (7.8 t ha-1) of maize. Application of atrazine followed by 2, 4-D recorded higher grain (59.9 q ha-1) and stover yield (8.1 t ha-1) over the rest of the treatments. The combined effect of conventional tillage with mulching and application of atrazine @ 1.25 kg a.i. ha-1 followed by 2, 4-D sodium salt @ 2.00 kg a.i. ha-1 and minimum tillage with mulching and application of atrazine @ 1.25 kg a.i. ha-1 followed by 2, 4-D @ 2.00 kg a.i. ha-1 enhanced the vegetative growth, yield attributes and economics of maize over the rest of the treatment combinations.