The strategic use of naturally occurring organisms to control pest populations and increase production of major crops represents a viable option to host-plant resistance in pest control. One group of biological control agents that provide a source for novel pest control is the mutualistic microbial symbionts, which are termed as “Endophytes”. Entomopathogenic endophytes play vital role in reducing pest load by imparting host defense mechanisms against various crop insect pests. In recent years, entomopathogenic endophytes have been explored for pest management in various countries. Unique endophytes could be used directly to treat seeds or transplants. The capability of colonizing internal host tissues has made endophytes valuable for agriculture as a tool to improve crop protection. In this paper, the major topics concerning the screening of microbial endophytes from different crop plants, induction of endophytes in to the plant, control of insectspests by endophytic microorganisms etc., have been reviewed and presented. Several examples of insect control are described, notably those involving the interactions between fungi and insect. The mechanisms by which endophytic fungi control insect attacks are listed and include toxin production as well as the influence of these compounds on plant and how their production may be affected by genetic and environmental conditions. The future use of biological–chemical combinations of endophytes in combination with commercial pesticides applied to the seed or seedling could lead to synergistic effects on one or multiple insect pests or disease causing agents. The chemicals could provide near instantaneous suppression on insect pests, while the biological agent could provide continuing control well into the crops production cycle.