A field experiment was conducted during kharif, 2015 at Agricultural Research Station, Gangavathi, Karnataka tostudy the bio efficacy of different herbicide molecules against weeds in dry direct seeded rice (Oryza sativa L.). Theexperiment comprised of 11 sequential applications of herbicides in randomized block design and replicated thrice. Thestudy revealed that hand weeding at 30 and 60 days after sowing recorded significantly lower weed density (2.39 0.25m-2),weed dry weight (3.02 g 0.25 m-2) and high weed control efficiency (80 %) and resulted in higher grain yield and net returns.Among herbicidal treatments pretilachlor 50 % EC @ 0.5 kg a.i. ha-1 (PRE) fb bispyribac sodium 10 % SC @ 35g a.i. ha-1(POE) at 2-4 leaf stage of weeds proved most effective in controlling weeds and recorded higher yield, net returns and BCratio. In contrast weedy check treatment recorded significantly lower grain yield, net returns and BC ratio.