A field experiment was carried out in vertisols at Agricultural Research Station, Dharwad during kharif 2015-16to assess the effect of different levels of drip irrigation and fertigation of N & K on seed cotton yield and water use efficiency(WUE). Three levels of drip irrigation viz., irrigation at 1.0 Etc, 0.8 Etc and 0.6 Etc and three levels of N & K (100%, 75%,and 50% of recommended dose of N & K) applied through fertigation were compared with furrow method of irrigation withbasal application of fertilizers. Significantly higher seed cotton yield (SCY) was recorded in drip irrigation at 1.0 Etc withfertigation of 100% N & K in six equal splits (4,024 kg ha-1), however it was on par with drip irrigation at 0.8 Etc and 75% N& K in six equal splits (3943 kg ha-1). Drip irrigation at 1.0 Etc with basal application of 100% RDF and furrow irrigationwith basal application of 100% RDF in four equal splits recorded significantly lower SCY. Significantly higher WUE wasobtained with drip irrigation at 0.8 Etc level (6.8 kg ha-1-mm) which was on par with 1.0 Etc level (6.6 kg ha-1-mm). Similarlyhigher water use efficiency was recorded at 100 per cent fertigation of RD N & K and it was on par with 75 per centfertigation of RD N & K. Drip irrigation at 1.0 Etc recorded significantly higher consumptive use of water (503.2 mm) ascompared to drip irrigation at 0.8 Etc and 0.6 Etc.