A field experiment was undertaken to study the effect of different fertigation levels with conventional and watersoluble fertilizers on seed cotton yield and economics of Bt cotton at the Agriculture Research Station, Dharwad, Karnatakaduring the kharif season of 2016-17. The results indicated that paired row (PR) sowing with fertigation of 100 per cent RDF(150:75:75 kg ha-1) through conventional fertilizers (CF) applied in six equal splits (T9) recorded significantly higher seedcotton yield ha-1 (40 q ha-1) than other treatments, but was on par with PR sowing with fertigation of 30 per cent RDF(45: 22.5: 22.5 kg ha-1) through water soluble fertilizer (WSF) and 25 per cent RDF through CF applied in six equal splitsi.e T5 (38.94 q ha-1) and PR sowing with fertigation of 25 per cent RDF (37.5: 19: 19 kg ha-1) through WSF and 25 per centRDF through CF applied in six equal splits i.e T6 (37.83 q ha-1). This higher seed cotton yield was mainly attributed tohigher seed cotton yield per plant, number of bolls harvested per plant, boll weight and number of sympodia per plant.Economic analysis also revealed that PR sowing with fertigation of 100 per cent RDF (150:75:75 kg ha-1) through CFapplied in six equal splits (T9) recorded highest gross returns (` 2,20,018 ha-1), net returns (` 1,46,115 ha-1) and benefit cost(BC) ratio (2.97) as compared to other treatments. PR sowing with fertigation of 30 per cent RDF (45: 22.5: 22.5 kg ha-1)through WSF along with 25 per cent RDF through CF applied in six equal splits i.e T5 and PR sowing with fertigation of 25per cent RDF (37.5: 19: 19 kg ha-1) through WSF along with 25 per cent RDF through CF applied in six equal splits i.eT6 recorded comparable economics with T9.