Nothapodytes nimmoniana is one of the important commercialisedmedicinal tree; exported for its novel alkaloid camptothecin. The useof eco-friendly disease management practices (bioagents and plantextracts) is of paramount importance in order to avoid the residuetoxicity in the host plant. Therefore, different bio agents and plantextracts were evaluated under in vitro conditions. Among the differentfungal bio agents, Trichoderma harzianum (IOF strain) has exhibitedmaximum zone of inhibition (99.81%). Among the bacterial antagonistsPseudomonas fluorescens (IOF strain) has shown maximum growthinhibition of 70.74 per cent followed by Bacillus subtilus; (IOF strain)inhibited 51.48 per cent. Among the various plant extracts usedAzadiractha indica has inhibited the maximum growth of the pathogento an extent of 98.40 per cent and 100 per cent at 5 and 10 per centconcentration, respectively.