A field experiment was carried out to study the effect of treated and untreated domestic wastewater and fertilizerlevels on tomato during 2014 and 2015 at the Main Agricultural Research Station, University of agricultural Sciences,Dharwad. The experiment comprised of four irrigation sources (I1- treated domestic wastewater, I2- fresh water,I3- untreated domestic wastewater alternated with fresh water, and I4- untreated domestic wastewater) and four fertilizerlevels (0, 50, 75 and 100 % RDF). The interaction effects of application of untreated domestic wastewater along with100 per cent RDF resulted in significantly higher plant height (77.93 cm), leaf area (91.57 cm2), LAI (2.03) and dry matterproduction (106.03 g plant-1) as compared to other treatment combinations. However, LAI (1.87) and dry matter production(93.04 g plant-1) were found on par with treatment receiving treated domestic wastewater along with 100 per centRDF(250:250:250 kg N, P2O5 and K2O ha-1). Among irrigation sources significantly higher yield parameters like averagefruit weight and fruit diameter were noticed with application of either treated or untreated domestic wastewater ascompared to other irrigation sources. Fruit yield differed significantly due to application of different sources of irrigationand fertilizer levels. Among irrigation sources significantly higher fruit yield (58.20 t ha-1) was recorded with application ofuntreated waste water as compared to other irrigation sources. However, it was on par with treatment receiving treatedwaste water (56.59 t ha-1). Among fertilizer levels significantly higher fruit yield (68.81 t ha-1) was recorded with applicationof 100 per cent RDF as compared to other fertilizer levels. Among interaction effect significantly higher fruit yield wasrecorded with application untreated wastewater along with application of 100 per cent RDF (73.30 t ha-1) as compared toother treatment combinations. However, it was on par with application of treated wastewater along with application of100 per cent RDF (71.88 t ha-1).