An investigation was undertaken with an objective to document indigenous hypoglycemic substances by diabetics of North Karnataka region and Five zones viz, dry, coastal, hilly, transitional and north eastern transitional zones were selected randomly from North Karnataka region for documentation study with 30 type 2 diabetics in each zone. About 20 indigenous hypoglycemic substances were documented in North Karnataka.  All the substances were of plant origin, which included herbs (n=10), green leafy vegetables, fruits  (n=2), other vegetables  (n=3) and spices (n=2). These substances were consumed by  diabetics in the form of dry powder, fresh, decoction and juices.  Aleo vera, bael leaves, heart leaf, hibiscus flower, neem, madhu nasini, periwinkle, tulasi, curry leaves, drumstick leaves, bitter gourd and snake gourd were consumed in fresh form.  Banyan bark, khus grass, amla, jumbu seed powder and fenugreek seeds were taken in powder form for the control of diabetes.