Afield experiment was conducted to evaluate the post emergence herbicides in irrigated maize. The experimentwas laid out in Randomized Complete Block Design with three replications and 17 treatments. The treatments included preemergence application of atrazine alone or in combination with pendimethalin and post emergence application of atrazineand 2,4-D sodium salt alone or in combination with tembotrione, topramezone or halosulfuron. These treatments werecompared with hand weeding, weed free check and weedy check. The results revealed that atrazine 50 WP @ 0.625 kg a.i.ha-1+ pendimethalin 38.7 CS @ 0.9675 kg  a.i. ha-1followed by hand weeding at 40 days after sowing (DAS) recorded thelowest number of weeds (3.67/0.5 m2), weed dry weight (7.30 /0.5 m2), highest weed control efficiency (87.8 %) and lowestweed index (2.38%). Further, these attributed in higher grain yield (5046 kg ha-1), net returns (`5046 kg ha-1) and BC ratio(2.91).  Among the post emergence application of herbicides, application of atrazine @ 1.25 kg  a.i. ha-1+ topramezone @0.0252 kg a.i. ha-1at 20 DAS and atrazine @1.25 kg a.i. ha-1+ tambotrione @ 0.0482 kg a.i. ha-1at 20 DAS were found tobe the profitable weed control practices.Key words:Grain yield, Tembotrione,  Topramezone, Weed control efficiency ,  Weed index