Studies were conducted to evaluate the bio-efficacy of Chlothianidin 50 % WDG (Dantop) a new insecticide spray formulation at different dosages along with standard checks (imidacloprid and Acetamiprid) to combat cotton sucking pests under irrigated cotton for two seasons.  Results of pooled analysis indicated that two sprays of Clothianidin 50% WDG @ 20 and 25 gai/ha rendered very good protection of crop against the early season sucking pests.  Significantly highest seed cotton yield (11.29 q/ha) was harvested from the Clothianidin 50% WDG @ 25 gai/ha treated plots which was on par with Acetamiprid 20 SP @10 gai/ha and to its next lower dose @ 20 gai/ha (10.97 q/ha).  There was no phytotoxicity of Clothianidin 50% WDG treatments on the cotton hybrid DHH-11.