Five systemic and five non-systemic fungicides were tested in two concentrations in vitro against C. paradoxa causing sett rot of sugar cane. Among the systemic fungicides carbendazim and propiconazole were most effective in complete inhibition of the pathogen at both the concentrations (0.05 and 0.1%), while benomyl and hexaconazole only at 0.1 per cent concentration. Among the non-systemic fungicides tested thiram was found best followed by captan at both the concentrations (0.1 and 0.2%), whereas mancozeb and copper oxychloride were least effective. Systemic fungicides were found more effective in controlling the pathogen growth than that of non-systemic fungicides.