Forty five hybrids of sesame developed by crossing 10 parents in half diallel fashion along with parents wereevaluated in RBD with two replications during kharif, 2019 for heterosis. The analysis of variance (half diallel) revealedsignificant differences among genotypes for all the characters studied. Out of 45 crosses, high degree of significant desirableheterosis over mid parent, better parent and standard check was observed for the major traits, seed yield per plant, 1000seed weight, oil content and number of capsules per plant. The cross JTS-8 x AKT-101 recorded highest positive heterosisover better parent and standard check (DS-5) for seed yield per plant, IC-204845 x AKT-101 over better parent and DS-5 x JLT-408 over standard check for oil content, MT-10-8-1 x AKT-101 over better parent and RMT-430 x AKT-101 overstandard check for number of capsules per plant and JTS-8 x RMT-430over better parent and JTS-8 x AKT-101 overstandard check for 1000 seed weight