The cotton flower bud midge, Dasineura gossypii Fletcher (Cecidomyiidae: Diptera) has recently been reported as key pest of cotton in Southern parts of India. The laboratory studies have been carried out during 2014-16 on the efficacy of six commercially available insecticides viz., Lambda Cyhalothrin 5 EC, Fipronil 5 SC, Profenophos 50 EC, Quinalphos 25 EC, Spinosad 45 SC and Rynaxypyr 18.5 EC against cotton flower bud midge. In CDC bottle assay method, Lambda Cyhalothrin 5 SC, Profenophos 50 EC and Quinalphos 25 EC were found to be the most effective against adults with highest per cent mortality (100%) while, Fipronil 5 SC, Spinosad 45 SC and Rynaxypyr 18.5 EC were found to be least effective insecticides. Lambda Cyhalothrin was found to be effective with comparatively very low LT50 of 4.56 and 2.80 min at 10 and 100 ppm, respectively, followed by quinalphos and profenophos. As the pupation of this insect pest happens in the soil and debris, management of pupae with soil application of insecticides can be done. Accordingly, the soil application assays conducted with three insecticides viz., Phorate 10 G, Carbofuran 3 G and DDVP 76% EC, against maggots of cotton FBM indicated that DDVP 76% EC found to be the most effective with the lowest adult emergence (3.33 %) followed by Phorate (5.56 %) as against 55 % in control.